New book on the exposome coming in Summer, 2020
- N6-methyladenosine of Chromosome-Associated Regulatory RNA Regulates Chromatin State and Transcription
- Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice Following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)
- Simulations show extreme opinions can lead to polarized groups
- Dispersion of the quantum many-body states ‘Bethe Strings’ experimentally resolved
- Personalized microrobots swim through biological barriers, deliver drugs to cells
- Innovative technologies for satellites
- Lipid gradient that keeps your eyes wet
- Proposed SwRI/UNH mission LEAPs forward
- Cancer scientists at Purdue aim to use protein power to stop tumor growth
- Are gamma-ray bursts powered by a star’s collapsing magnetic fields?
- Atomic force microscopy reveals high heterogeneity in bacterial membrane vesicles
- How serotonin balances communication within the brain
The human exposome is the environmental equivalent of the human genome. It is a representation of the complex exposures we are subjected to throughout our lives, including our diet, lifestyle factors, and social influences. It also incorporates how our bodies respond to these challenges. The exposome encompasses much of what we refer to as nurture. The term exposome was coined by Dr. Christopher Wild at the International Agency for Research on Cancer, World Health Organization.
Several academic and government laboratories across the world are collecting data that can contribute to our understanding of the exposome. Our goal is to bring these investigators together to formulate a plan to define the exposome in a way that is useful to those in health care and public health, to identify gaps in knowledge or technique, and to help develop a new generation of scientists who focus on these complex environmental influences on health. The Human Exposome Project will build upon the already existing resources and work to identify additional funding to pursue the important questions in the field.
The rapid advancement in the areas of genetics and genomics has transformed our understanding of human biology. However, genome-wide association studies (GWAS) have only been able to account for a minority of disease risk. Quantitative data on the environmental factors that influence health are desperately needed. The Human Exposome Project can help provide this important information in a form that can be used to directly impact human health.