Exposome Journal Club

In the Spring 2021 semester, the Columbia University Department of Environmental Health Sciences Journal Club will focus on the exposome. We will be posting information about the course as the semester progresses. 

January 11, 2021       1. Introduction and the Wild papers

*Wild CP. Complementing the genome with an “exposome”: the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50. doi: 10.1158/1055-9965.EPI-05-0456. PMID: 16103423.

Wild CP. The exposome: from concept to utility. Int J Epidemiol. 2012 Feb;41(1):24-32. doi: 10.1093/ije/dyr236. Epub 2012 Jan 31. PMID: 22296988.

In our first session, Dr. Miller gave an overview of the course structure and discussed these two key papers from Dr. Chris Wild. He spent most of the time on the 2005 paper which introduced the term and laid the foundation for the establishment of the field. It is hard to believe that it was published over 15 years ago. 

January 25, 2021  2. The Berkeley Papers. 

Rappaport SM, Smith MT. Epidemiology. Environment and disease risks. Science. 2010 Oct 22;330(6003):460-1. doi: 10.1126/science.1192603. PMID: 20966241; PMCID: PMC4841276.*

*Rappaport SM. Implications of the exposome for exposure science. J Expo Sci Environ Epidemiol. 2011 Jan-Feb;21(1):5-9. doi: 10.1038/jes.2010.50. Epub 2010 Nov 17. PMID: 21081972.

Rappaport SM. Genetic Factors Are Not the Major Causes of Chronic Diseases. PLoS One. 2016 Apr 22;11(4):e0154387. doi: 10.1371/journal.pone.0154387. PMID: 27105432; PMCID: PMC4841510.

In our second meeting, Dr. Miller discussed the 5 year hiatus from the original Wild paper and highlighted the work of Steve Rappaport and Martyn Smith at UC Berkeley who helped advance the exposome concept in the U.S. We discussed the 2010 NAS meeting on the exposome and how 2010 represented a new beginning in the field.

February 1, 2021       3. Nature vs. Nurture,  Exposure vs. Biology

Miller GW, Jones DP. The nature of nurture: refining the definition of the exposome. Toxicol Sci. 2014 Jan;137(1):1-2. doi: 10.1093/toxsci/kft251. Epub 2013 Nov 9. PMID: 24213143; PMCID: PMC3871934.

Dennis KK, Auerbach SS, Balshaw DM, Cui Y, Fallin MD, Smith MT, Spira A, Sumner S, Miller GW. The Importance of the Biological Impact of Exposure to the Concept of the Exposome. Environ Health Perspect. 2016 Oct;124(10):1504-1510. doi: 10.1289/EHP140. Epub 2016 Jun 3. PMID: 27258438; PMCID: PMC5047763.