Mutagenesis highlights exposomics research

In this month’s issue of Mutagenesis, the journal highlights exposomics in a special topic series. Dr. Paolo Vineis,director of the European EXPOsOMICS project, introduces the series with his commentary, Exposomics: mathematics meets biology. Dr. Vineis emphasizes that a proof-of-principle for exposome research has so far been lacking. Through the Mutagenesis series, the authors aim to help fill that gap through highlighting a few examples of current exposome research along with opportunities for future studies.

The articles are highlighted below. As interest in exposome research continues to grow, case studies and proof of concept examples are exactly what is needed to help move the discussion and the research forward.

The exposome concept in a human nutrigenomics study: evaluating the impact of exposure to a complex mixture of phytochemicals using transcriptomics signatures. van Breda SGJ, Wilms LC, Gaj S, Jennen DGJ, Briede JJ, Kleinjans JCS, et al.


Characterising the epigenome as a key component of the fetal exposome in evaluating in utero exposures and childhood cancer risk. Ghantous A, Hernandez-Vargas H, Byrnes G, Dwyer T, Herceg Z.

A statistical framework to model the meeting-in-the-middle principle using metabolomic data: application to hepatocellular carcinoma in the EPIC study. Assi N, Fages A, Vineis P, Chadeau-Hyam M, Stepien M, Duarte-Salles T, et al.

Metabolic profiling in human exposome studies. TJ Athersuch and HC Keun.