Biomedical Computation Review recently published “Taking on the Exposome: Bringing Bioinformatics Tools to the Environmental Side of the Health Equation.” Kristin Sainani, PhD, reviews progress in exposome research, including recent Environment-Wide Association Studies and novel data collection techniques, as well as significant remaining challenges in collecting, analyzing, and interpreting exposome data. The article concludes with a call from Christopher Austin, MD, to adopt a “big science” approach akin to the Human Genome Project, with investments in improving measurement techniques, establishing public databases with agreed upon standards, and strong community leadership. The full article is available online here.